MD Axon 1-PATCH-1U Model Cell

MD Axon 1-PATCH-1U Model Cell
Simulates whole-cell clamp and single-channel patch-clamp conditions. Connectors are suitable for U-type CV series headstages.

Descriptions of 1-PATCH-1U Model cell
⦁ Patch position uses a 3.3 pF capacitor (in parallel with 10 GΩ resistor).
⦁ The accuracy of this capacitance is ± 0.5 pF
⦁ Wiring capacitance adds about 1 pF.
⦁ Patch-1U has an input loading of 3.8 pF to 4.3 pF in PATCH position.
⦁ BATH and CELL positions do not include separate capacitors, but shares the same input capacitance loading as the PATCH position.
⦁ CELL position of the Patch-1U uses and additional 33 pF (whole-cell) capacitance with 10% accuracy.
⦁ Measured whole-cell capacitance should fall between 30 pF and 36 pF.
⦁ The accuracy of the resistors used in the Patch-1U model cell are 1% for the 10 MΩ (BATH), and 5% for the 500 MΩ (CELL) and 10 GΩ (PATCH).

Features and Applications of the MD Axon 1-PATCH-1U Model Cell:
Patch-Clamp Amplifier:
-It used in patch-clamp amplifier or an accessory used in patch-clamp experiments. These amplifiers are essential for measuring the electrical currents that flow through ion channels in the membranes of individual cells.
-The "1U" designation might refer to the 1U rack-mountable design, meaning it fits in a standard 19-inch rack, which is common for electrophysiology equipment.

Single-Cell Recording:
-The device  used for single-cell recordings in which the experimenter measures ion channel activity or membrane potentials in individual cells, such as neurons or muscle cells.
-This would involve high-resolution, low-noise data acquisition and precise control over the membrane potential of the cell.

Low-Noise Measurement:
Given that patch-clamp experiments involve detecting very small electrical signals, such a device would likely be designed to ensure minimal noise to capture clean signals from small biological currents.

Versatility in Electrophysiology:
The MD Axon 1-PATCH-1U Model Cell  used in a variety of applications, such as:
Neuroscience research, including studying synaptic activity, neural signaling, and neuron ion channels.
Pharmacological testing, where the effects of various drugs or compounds on ion channels or cellular activity are assessed.
Cardiac research, investigating ion channels in heart cells or other excitable tissues.
Biomedical research, specifically in studying the behavior of individual cells under controlled electrical conditions.

Software Integration:
If it is part of the Axon product line, it likely integrates with software tools like pCLAMP for data acquisition, visualization, and analysis of patch-clamp data.

Compact, Efficient Design:
The 1U model suggests that it is a compact, efficient unit designed for lab environments where space may be limited. It would offer easy integration into existing setups for electrophysiology or neuroscience research

Products
Axopatch 200B amplifier, MultiClamp 700, Axoclamp 900A amplifier, Axoporator 800, Digidata 1550, pCLAMP/AxoScope.